Toxicology and Safety Assessment
Services: Efficacy and Safety Pharmacology |
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Core Battery and Supplementary Tests
As part of its efficacy and safety pharmacology service offering, Covance offers a complete range of GLP-compliant ICH S7A (PDF) core battery tests to determine potential undesirable pharmacodynamic effects of a drug on the cardiovascular, respiratory and central nervous systems, as well as supplementary tests to evaluate other organ systems. |
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Follow-up Tests |
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Supplementary Tests |
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Cardiovascular system |
- Chronically instrumented conscious canine and nonhuman primate models using radiotelemetry
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Respiratory system |
- Rodent whole body and head-out plethysmography
- Arterial blood gas in nonhuman primates
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Central nervous system |
- Modified Irwin test in rodents
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Purkinje fiber assay |
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hERG trafficking |
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Echocardiography |
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Gastrointestinal system |
- Gastrointestinal transit time
- Gastric damage
- Gastric secretion (pyloric ligation)
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Renal system |
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Abdominal spasm test |
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Analgesic assessment |
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Sleeping time |
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Tail flick |
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Body temperature |
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Convulsant activity |
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Motor in-coordination (rotarod) |
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Bleeding time |
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Designing a Comprehensive Cardiovascular Safety Testing Regimen
Ian MacKenzie and Dusty Sarazan
Covance Evolutions Newsletter
Volume 10, No. 1, July 2005
 Download PDF |
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