Food & Dietary Supplements
Residues |
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Although agricultural and industrial practices have drastically changed in recent decades, the threat of harmful residues in foods remains a major concern in the minds of consumers. Covance has staff in both the U.S. and Europe whose expertise in agrochemical and residue analysis spans decades. We have validated methods for many classes of compounds and are actively involved in initiatives for worldwide harmonization of residue assays. Utilizing modern analytical technology, our chemistry expertise and knowledge of global regulations, we have developed low-cost and high-throughput pesticide screens that can screen for hundreds of pesticides for less than $1 per compound. If a pesticide is detected, confirmatory analysis using additional chromatographic or mass spectrometry techniques can be done to provide more comprehensive data. For analysis of heavy metals, Covance utilizes the latest in inductively coupled atomic emission spectrometry to screen for the presence of metals at minute levels. In addition, Covance has traditionally been quick to respond to new high profile concerns such as the presence of acrylamide. Covance was an early leader in validation of a dependable and efficient acrylamide method and has analyzed thousands of samples from a variety of matrices.
To view and order copies of Covance articles on residues please visit our Publications page.
FDA Residue Screens
FDA PAM 302 Screen
Gas chromatography/high performance liquid chromatography
Food and Drug Administration, '302: Method II for Nonfatty Foods', Pesticide Analytical Manual, Third Edition, Vol. 1, Food and Drug Administration, Washington, D.C. (1994)
FDA PAM 303
Gas chromatography/high performance liquid chromatography
Food and Drug Administration, '303: Method II for Nonfatty Foods', Pesticide Analytical Manual, Third Edition, Vol. 1, Food and Drug Administration, Washington, D.C. (1994)
FDA PAM 304 Screen GC/HPLC
Gas chromatography/high performance liquid chromatography
Food and Drug Administration, '304: Method II for Nonfatty Foods', Pesticide Analytical Manual, Third Edition, Vol. 1, Food and Drug Administration, Washington, D.C. (1994)
Chlorinated Pesticides
Gas chromatography
Journal of the Association of Official Analytical Chemists, 70:724-726, (1987) (Modified)
FDA Pesticide Analytical Manual, Volume 1, Section 121.3-121.33 and 252. Journal of the Association of Official Analytical Chemists, 57:168-172, (1974) (Modified)
Journal of the Association of Official Analytical Chemists, 48:1158-1160, (1965). (Modified)
Bulletin of Environmental Contamination and Toxicology, 12(6):717-720. Laboratory Information Bulletin, Number 2722
Organophosphate Pesticides
Gas chromatography
FDA Pesticide Analytical Manual, Volume 1, Section 121.3-121.33 and 252. Journal of the Association of Official Analytical Chemists, 57:168-172, (1974) (Modified)
Journal of the Association of Official Analytical Chemists, 70:724-726, (1987)
(Modified)
Journal of the Association of Official Analytical Chemists, 48:1158-1160, (1965). (Modified)
Bulletin of Environmental Contamination and Toxicology, 12(6):717-720. Laboratory Information Bulletin, Number 2722
Chlorinated and Organophosphate Pesticides
Gas chromatography
FDA Pesticide Analytical Manual, Volume 1, Section 121.3-121.33 and 252. Journal of the Association of Official Analytical Chemists, 57:168-172, (1974) (Modified)
Journal of the Association of Official Analytical Chemists, 70:724-726, (1987) (Modified)
Journal of the Association of Official Analytical Chemists, 48:1158-1160, (1965). (Modified)
Bulletin of Environmental Contamination and Toxicology, 12(6):717-720. Laboratory Information Bulletin, Number 2722
Triazine and Chloracetamide Herbicides
Gas chromatography
Pesticide Analytical Manual, Volume II, Pesticide Regulations Section 120.213 Quantitative Determination of Triazine Herbicides, Ciba Geigy (1969)
Chlorphenoxy Acid Herbicides
Gas chromatography
Food and Drug Administration, Pesticide Analytical Manual, Vol. 1, Section 221.1 Food and Drug Administration, Washington, D.C. (1994). (Modified)
N-Methyl Carbamates
High performance liquid chromatography
Environmental Protection Agency, Office of Ground Water and Drinking Water, Method 531, Cincinnati, OH, USA, 2001
Pheyl Urea Herbicides
Food and Drug Administration, '403: Method for Phenylurea Herbicides' (modified), Pesticide Analytical Manual, Third Ed., Vol. 1, Food and Drug Administration, Washington, D.C. (1994)
Other Pesticides, Herbicides and Fungicides
Please contact Client Service Coordinator
USP-NF Pesticides
PCNB (Quintozene) and Degradants
Gas chromatography
Food and Drug Administration, '303: Method II for Nonfatty Foods', Pesticide Analytical Manual, Third Edition, Vol. 1, Food and Drug Administration, Washington, D.C. (1994)
Aflatoxins
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 991.31. (Modified)
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 970.45. (Modified)
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 993.17. (Modified)
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method 994.08. (Modified)
Heavy Metals
Arsenic
Hydride generation
Analytical Methods Committee, The Analyst, 85:643-656 (1960). (Modified)
Analytical Methods using the MHS Mercury/Hydride System, Perkin-Elmer: Norwalk,
Connecticut, (January 1981). (Modified)
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Method 952.13. (Modified)
Wet Chemistry
Food Chemicals Codex, Fourth Edition, p.755, National Academy Press: Washington, DC (1996). (Modified)
The United States Phamacopeia, Twenty-Fifth Revision, United States Pharmacopeial Convention, Inc.: Rockville, Maryland (2002). (Modified)
Cadmium
Graphite furnace or Atomic Absorption
Methods for Chemical Analysis of Water and Wastes, Metals 1-19 and Method 239.2, US. EPA, Cincinnati, Ohio (1979). (Modified)
Test Methods for Evaluating Solid Waste, EPA Publication No. SW-846, Third Edition, Methods 3020 and 7131, U.S. EPA, Washington, D.C. (September 1986). (Modified)
Contract Laboratory Program Statement of Work No. 788, Method 213.2 CLP-M, U.S. EPA, Washington, D.C. (July 1988). (Modified)
Heavy Metals (e.g., lead)
Food Chemical Codex, Fourth Ed., pp.760-762, National Academy Press: Washington, D.C. (1996). (Modified)
Lead
Atomic absorption
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed., AOAC
INTERNATIONAL, Gaithersburg, MD, USA, Official Methods 972.23, 973.35, 974.27.
(Modified)
Friend, M. T., Smith, C. A., and Wishart, D., Atomic Absorption Newsletter, 16(2):46-49, (1979). (Modified)
Graphite furnace
Slavin, W., "Graphite Furnace AAS, A Source Book," Perkin-Elmer Corporation, Spectroscopy Division, Ridgefield, Connecticut, 1984.
Voth-Beach, L.M., and Shrader, D.E., "Graphite Furnace Atomic Absorption Spectroscopy: New Approaches to Matrix Modification," Spectroscopy, 1 (10), 1986.
General Guidelines for Microwave Sample Preparation, Applications Manual, CEM Corporation, 1991
Mercury
Cold vapor
Analyst, 86:608, 1961. (Modified)
Analytical Chemistry, 40:2085, 1968. (Modified)
Acrylamide
Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS)
United States Food and Drug Administration, Center for Food Safety and Applied Nutrition Office of Plant & Dairy Foods and Beverages, "Detection and Quantitation of Acrylamide in Foods" (2002) |
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