Food & Dietary Supplements
Botanicals |
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For centuries, people have used herbs and other botanicals for their healthful effects and in recent years, the use of these products has experienced an atmospheric rise in popularity among consumers. This has resulted in corresponding regulatory initiatives and the accelerated need for analytical methods for botanical products. Covance has been actively involved in the development and validation of assays to confirm the identity of the compounds of interest and assure that they are not adulterated or contaminated with pesticide residues or other impurities. Although researchers have been hampered by issues such as the lack of reference standards and a dearth of collaborative data, Covance has focused the efforts of significant resources on assuring we can provide accurate and regulatory compliant data for the labeling of all currently significant compounds. Several regulatory initiatives, including proposed changes to the Current Good Manufacturing Practices (cGMP), address the issue of appropriate testing requirements for botanical ingredients. Covance has the expertise and resources necessary to generate the data required to meet evolving regulatory mandates and fickle consumer attitudes.
To view and order copies of Covance articles on botanicals please visit our Publications page.
Raw Ingredients
Anthocyannin (bilberry, grape seed)
High performance liquid chromatography
Please contact a Client Service Coordinator
Cranberry (organic acids)
High performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
986.13. (Modified)
Clover (isoflavones)
High performance liquid chromatography
Seo, A. and Morr, C.V., "Improved High-Performance Liquid
Chromatographic Analysis of Phenolic Acids and Isoflavonoids from
Soybean Protein Products," J. Agric. Food Chem., 32(3): pp 530-533, 1984
Dong Quai (ferulic acid)
High performance liquid chromatography
Hagerman, A.E., Nicholson, R.L., "High-Performance Liquid
Chromatographic Determination of Hydroxycinnamic Acids in Maize
Mesocotyl," Journal of Agricultural and Food Chemistry, 30 (No. 6):
1098-1102, (1982), Modified
Echinacea (cichoric and chlorogenic acid)
High performance liquid chromatography
Economic and Medicinal Plant Research, Vol. 5, H. Wagner and Norman
Farnsworth Ed., Academic Press, 1991, p.253-321
Ephedra or Ma Huang (Ephedra alkaloids)
High performance liquid chromatography
Planta Medica 1988 pp. 69-70 (modified)
Evening Primrose Oil (linoleic acid & GLA)
Gas chromatography
American Oil Chemists' Society, 'Ce 1-62 Fatty Acid Composition by Gas
Chromatography' (modified), Official Methods and Recommended Practices f
the AOCS, Fifth Ed., American Oil Chemists' Society, Champaign, IL (1997)
Feverfew (parthenolide)
High performance liquid chromatography
Please contact a Client Service Coordinator
Garlic (allicin)
High performance liquid chromatography
Simultaneous Determination of Allicin and Allicin in Allium Plants and Their
Products by Liquid Chromatography, Journal of AOAC International, Vol. 80,
No. 5, 1997
Ginkgo Biloba
Ginkgoflavone glycosides
High performance liquid chromatography
Journal of Chromatography (modified), 605: 41-48 (1992)
Ginkgo terpenoids
High performance liquid chromatography
Journal of Chromatographic Science (modified), 36: April (1998)
Ginseng, (ginsenosides)
Panax or Korean
High performance liquid chromatography
Journal of Chromatography, 736 (1996) 77-81
Siberian
High performance liquid chromatography
Chem. nat. compd. (English translation) vol. 28, no. 1, July 1992, pp. 36-39
Grapes/Raisins (tartaric acid) HPLC
High performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
986.13. (Modified)
Grape Seed (anthocyanins)
High performance liquid chromatography
Please contact a Client Service Coordinator
Green Tea (phenols & caffeine)
UV detection
Please contact Client Service Coordinator
Guarana (caffeine)
Gas chromatography
Journal of Food Science (modified), 48: 745-747, (1983)
Isflavones (soy, kudzu, clover)
Gas chromatography
Seo, A. and Morr, C.V., "Improved High-Performance Liquid
Chromatographic Analysis of Phenolic Acids and Isoflavonoids from
Soybean Protein Products," J. Agric. Food Chem., 32(3): pp 530-533, 1984
Kudzu (isoflavones)
High performance liquid chromatography
Seo, A. and Morr, C.V., "Improved High-Performance Liquid
Chromatographic Analysis of Phenolic Acids and Isoflavonoids from
Soybean Protein Products," J. Agric. Food Chem., 32(3): pp 530-533, 1984
Lycopene (tomato)
High performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
941.15. (Modified)
Official and Tentative Methods of the American Oil Chemists Society,
Method CE 1-62, AOCS, Champaign, Illinois, (1981), modified
Nettle Root (phytosterols)
Gas chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
994.10. (Modified)
Pygeum (beta-sitosterol)
Gas chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
994.10. (Modified)
Rose Hips (vitamin C)
Fluorometric
Saw Palmetto (phytosterols & fatty acids)
Gas chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
996.06. (Modified)
Soy (isoflavones)
Gas chromatography
Seo, A. and Morr, C.V., "Improved High-Performance Liquid
Chromatographic Analysis of Phenolic Acids and Isoflavonoids from
Soybean Protein Products," J. Agric. Food Chem., 32(3): pp 530-533, 1984
St. John's Wort (hypericin, pseudohypericin)
High performance liquid chromatography
High-Performance Liquid Chromatographic Determination of the Biologically
Principle Hypericin in Phytotherapeutic Vegetable Extracts and Alcoholic
Beverages," Journal of Chromatography A, 731: 336-339, 1996
Tomato (lycopene)
High performance liquid chromatography
Official Methods of Analysis of AOAC INTERNATIONAL (2000) 17th Ed.,
AOAC INTERNATIONAL, Gaithersburg, MD, USA, Official Method
941.15. (Modified)
Valerian (valerenic acid)
High performance liquid chromatography
Please contact a Client Service Coordinator
Quackenbush, F. W., Journal of Liquid Chromatography, 10: 643-653,
(1987). (Modified) |
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